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There is no cure for migraine, and current medications primarily provide symptomatic relief and may not be suitable for all patients ( Therefore, this review elucidates the etiology, inducements, pathogenesis and treatment modalities of migraine, the clinical evidence that migraine is associated with oxidative stress and neurogenic inflammation, as well as the experimental evidence of antioxidant and anti-inflammatory effects of topiramate, which is of great significance for further research and exploration of the possible mechanisms of topiramate in the treatment of migraine by modulating oxidative stress and neurogenic inflammatory pathways
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Because accurate determination of the NADPH consumption rate can be confounded by the reduction rate of NADP + , we inhibited key biochemical pathways that reduce NADP + back to NADPH in LPS-stimulated Ms, including glucose-6-phosphate dehydrogenase (G6PD), isocitrate dehydrogenases and folate-mediated one carbon metabolism that can contribute to the reduction of NADP + [1820]
Manda, G
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