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, Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial, Lancet Diabetes Endocrinol

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It enhances the ER stress by upregulating the chaperone and non-chaperone proteins 26 resulting in morphological perturbation of ER