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Ozempic (semaglutide), a GLP-1 receptor agonist approved for type 2 diabetes and widely prescribed off-label for weight loss, has been linked to serious gastrointestinal injuries including bowel obstruction and ileus , or intestinal paralysis

This is especially important if youre pregnant, breastfeeding, managing a health condition, or taking prescription medications

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Patients on any oral antihyperglycemic agent in monotherapy (N=212) or on a PPAR agent in combination therapy (N=106) or not on an antihyperglycemic agent (off therapy for at least 8 weeks, N=34) were switched to monotherapy with pioglitazone (at a dose of 30-45 mg per day), and completed a run-in period of approximately 12 weeks in duration

In obese individuals without diabetes, Zepbound users achieved up to ~20.9% weight loss at 15 mg over 72 weeks