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The study strictly adhered to the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines and was conducted following the national regulations for the ethical use and care of laboratory animals

However, this aberrant activation state precipitates excessive inflammation

Postlethwaite TL, et al

We reasoned that if decreases in glutathione and glutamate in the stable phase are a consequence of damage arising in a preceding acute phase, a sample of stable patients would be more likely to demonstrate a reduction in these neurochemicals than a more heterogeneous sample