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Other mechanisms underlying the effects of GLP-1 RAs on exercise capacity include improvements in myocardial energetics, enhanced endothelial function, reductions in systemic inflammation and oxidative stress and modulation of skeletal muscle metabolism
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A possible explanation might be the close active site Tyr116, which is vital for substrate binding (Johnson et al., in vivo binding of 4-bromophenol in rat GSTM2 and confirmed adducts by radioactive labeling, tryptic digestion and LC-MS/MS
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