A key molecular buffer against this oxidative state is GSH
Besides, by upregulating the cytochrome c oxidase 2 (SCO2) (167), TP53 initiates several transcriptional programs to promote the expression of genes related to mitochondrial biogenesis (168), such as apoptosis-inducing factor (AIF) (169, 170) and ferredoxin reductase (FDXR) (171)
3.4 Increased expression of serine proteases contributes to stress response A significant increase in the abundance of five serine protease family members (log 2 FC = 2.06, 1.39, 1.29, 0.85, 0.65) was observed in Pc GKB4 following in vitro Phi treatment (Supplementary Table S1)
Peroxynitrite: A multifaceted oxidizing and nitrating metabolite
This thiol group is reactive and can donate a hydrogen atom to neutralize free radicals and other reactive oxygen species, thereby protecting cells from oxidative stress