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However, for anyone with a history of arrhythmia or tachycardia, this signal warrants a formal evaluation by a cardiologist before initiating the drug
However, years later in 2016, a pharmacological analysis of this ligand demonstrated interspecies differences between the rodent and human GIP system and also led to the conclusion that the human Pro3(GIP) was a potent partial agonist with the ability to activate the human GIP receptor with a maximal efficiency (E max ) of 90% compared to human GIP (68)
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Zheng, J., Devalaraja-Narashimha, K., Singaravelu, K
doi: 10.1080/17425255.2023.2223959 [PubMed] 37552484 Dart RC, Mullins ME, Matoushek T, Ruha AM, Burns MM, Simone K, Beuhler MC, Heard KJ, Mazer-Amirshahi M, Stork CM, Varney SM, Funk AR, Cantrell LF, Cole JB, Banner W, Stolbach AI, Hendrickson RG, Lucyk SN, Sivilotti MLA, Su MK, Nelson LS, Rumack BH
