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While these findings dont directly translate to humans, they raise legitimate concerns about reproductive health, endocrine disruption, and metabolic stress with prolonged, high-dose usage

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Isolation of polar metabolites For the metabolomics of tissues, 100200 mg of weighed tissue was homogenized in 1 ml of ice-cold 80% methanol with a QIAGEN Tissue Lyser II (three sets of 2 min on maximum speed, with 2 min of rest on dry ice in between sets)

Why Dosing Strategy Makes a Big Difference Both medications start at low doses to minimize side effects such as nausea or bloating

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