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Moreover, the Pt-induced ROS production further disturbs the normal function of DNA, mitochondria, microtubule, ion channels, and biomolecules, thus, inducing neuroinflammation, demyelination, and neuronal apoptosis in the process of PIPN (Lim et al., 2010

This receptor complex is distributed across several brain regions and peripheral tissues, where it participates in the regulation of appetite and energy balance

doi: 10.1016/S0140-6736(19)31149-3 16 GiuglianoD.MaiorinoM

Acta 1458 , 252262 (2000)

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