Scott Isaacs, MD, FACP, FACEs Post Reduced-frequency GLP-1 as a maintenance strategy: in this case series, patients who tapered from weekly semaglutide/tirzepatide to less frequent dosing maintained weight loss, body composition, and metabolic syndrome gains, supporting structured de-escalation to lower burden without sacrificing efficacy
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The same 2017 study referenced above reported the following side effects in some participants who received 250mg of oral glutathione:6 Pruritis (itching) Macular erythema (rash-like red patches on the skin) Red spots on the skin Tiredness Transaminitis (high liver enzyme levels in the blood) Additionally, specific glutathione supplements may pose more safety concerns than others
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Furthermore, the homeostasis of bone formation and resorption is essential to bone health and might be maintained by GLP-1 in normal bones and restored by GLP-1 in unhealthy bones