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Others experience fatigue from appetite suppression and caloric restriction
[1] All current GLP-1 therapy relies on established injectable formulations such as semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda), which have extensive clinical evidence supporting their efficacy and safety
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This is not proven for retatrutide specifically, but the principle is well-established for other peptides of comparable size
Reports vary considerably and include: Reduced emotional eating or changes in food-related reward responses Altered mood states, including feelings of flatness or reduced enthusiasm Changes in social behaviour or interest in activities previously enjoyed Shifts in anxiety levels or emotional reactivity It is important to emphasise that there is currently no established causal link between semaglutide and personality changes
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