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This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)

Oxidative Medicine and Cellular Longevity , 2012.PMID: 22900128 Review of GHK-Cu as an endogenous tripeptide that declines with age, with evidence for antioxidant, anti-inflammatory, and tissue-remodeling properties

As the field advances, standardized preclinical evaluation models, multi-omics integration, and AI-guided predictive design will be essential for translating these bioadaptive systems into clinical reality

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