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Preclinical studies in accelerated mouse models of diet-induced steatohepatitis have demonstrated that retatrutide improves steatohepatitis through mechanisms involving enhanced hepatic fat oxidation, reduced lipogenesis, decreased inflammation, and attenuation of fibrosis markers, supporting the rationale for clinical development in MASH [33]

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The FDAs approval, which came late Friday evening, makes Carvykti the first BCMA-targeted therapy in this treatment line, according to Legend Biotech

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