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The slowed gastric emptying at 1.0 mg is significant enough that food sits in the stomach much longer than usual, creating a persistent fullness and distension that some find quite uncomfortable

The clinical relevance of gastrointestinal adverse events associated with GLP-1 RAs depends not only on their incidence but also on their severity, duration, and impact on patient quality of life

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Per accedere alla matrice mitocondriale, gli acidi grassi di lunghezza pari o superiore a 14 atomi di carbonio, per la (beta) ossidazione e la produzione di ATP, devono essere attivati e successivamente trasportati mediante tre reazioni enzimatiche dello shuttle della carnitina