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Even when NPs are intended to traverse the bloodbrain barrier (BBB) for CNS delivery, neurotoxicity remains a concern: NPs can activate microglia, promote neuroinflammation, trigger excitotoxicity, and accumulate in neural tissue even without brain-targeting ligands

for others, it may take longer or require medical support

Sanchez-Mata A, Gonzalez-Muoz E

Secondary NAD+ deficiency in the inherited defect of glutamine synthetase