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Importantly, neuroinflammation-associated gene expression signatures are enriched for AD genetic risk loci and recapitulate transcriptional changes in human AD hippocampus, and these signatures are ameliorated by semaglutide treatment

Methods C2C12 cells were differentiated into myotubes by growing them in DMEM for 24 h (hrs) and then changing the media to DMEM supplemented with 2% horse serum