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Similar antagonistic effects of GRAs on GLP-1(936)s glucagonostatic effects were observed in human islets using the antagonists desHis 1 Pro 4 Glu 9 glucagon (peptide N) or desHis 1 Pro 4 Glu 9 Lys 12 PAL-glucagon (peptide R) [47] (ESM Fig
Drug Investig
The mean 9.4% BW reduction exhibited by patients treated with OW semaglutide 2.4 mg might partially explain the HF benefit observed in this trial 84 , as previously demonstrated for treatments leading to at least 10% weight loss 87
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