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When severe mitochondrial dysfunction triggers the spatial activation of the Integrated Stress Response (ISR) (often via the OMA1-DELE1-HRI axis), it strongly upregulates the transcription factor CHOP
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Earlier review-level data concluded that thermotherapy studies in knee osteoarthritis were limited and methodologically inconsistent, and at least one placebo-controlled trial of monochromatic infrared energy reported no meaningful benefit in body function, activity, participation, or quality of life (Brosseau et al., 2003)
Vahratian A, Warren A
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