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These channels affect gustatory processing by altering sensibility to changes in temperature (activated indirectly by tastants or directly by certain spices) in response to physical stimuli, such as mechanical forces and temperature, and by chemical agents (chemestesis), evoking sensations of touch, temperature, and pain, depending on the kind of subunit they are attached to
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The SURPASS trial program documented injection site reactions as generally mild to moderate in severity, with most reactions resolving spontaneously without intervention
Garca-Burgos, M., Moreno-Fernndez, J., Alfrez, M
71 These modulators can potentially provide more selective activation of the receptor, reducing adverse effects and improving efficacy
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