Nausea and vomiting are less frequent in patients receiving EX-LAR than in patients taking EX (114)
Toxicology assessments in rats found no organ toxicity at doses up to 10 mg/kg (approximately 1000x the effective dose), no mutagenicity in Ames testing, and no teratogenic effects
However, some patients receiving high-dose B12 supplementation or injections may experience adverse reactions, though these relate to the treatment rather than the elevated levels: Possible reactions to B12 supplementation (particularly injections): Skin reactions, including acneiform eruptions or rashes Pruritus (itching) Injection site reactions (with parenteral administration) Rare hypersensitivity reactions Non-specific symptoms such as headaches, dizziness, or gastrointestinal disturbances have been reported by some patients taking B12 supplements, but causality is not well established in clinical evidence
Full-B12 Injection injection is administered under the supervision of a healthcare professional
Effects of Glucagon-Like Peptide-1 Receptor Agonists on Glucocorticoid-Induced Osteoporosis Glucocorticoid (GC) treatment is the main cause of secondary osteoporosis