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For instance, administration must occur in a fasted state (at least 2-3 hours post-meal) because elevated insulin and blood glucose can significantly blunt the pituitarys response to secretagogues
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To identify IGF-1-mediated miRNA regulatory networks that cause temozolomide (TMZ) to be insensitive to glioblastoma multiforme treatment, on the basis of comprehensive analysis of multiple databases and in vitro experiments, Chen et al (104) confirmed that IGF-1 upregulated miR-513a-5p signaling reduced the sensitivity of glioma cells to TMZ by inhibiting the NEDD4L-inactivated Wnt/-catenin pathway
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