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Trends Pharmacol Sci (2012) 33(12):65668.10.1016/j.tips.2012.09.007 65 TewKDTownsendDM

[8] Moreover, the research team suggested that the peptide may have facilitated the recovery of blood flow in the ischemic muscle of the rat hind limb, as determined by laser Doppler scanning, indicating the compounds potential to promote angiogenesis

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However, significant pain usually indicates a technical problem rather than a medication issue