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Extrinsic factors, such as growth factors and neurotransmitters, secreted by the stem cell niche, diffusing from the nearby vasculature or released from synaptic connections relay the environmental influence onto the progression of neurogenesis in the adult hippocampus (see Figure 1)
MM/PBSA (Molecular Mechanics/Poisson-Boltzmann Surface Area) calculates the free energy difference between the ligand and the protein-ligand complex in various states, which helps evaluate the binding affinity of a ligand to a protein
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