At position fifteen, the amino acid histidine (His) is replaced with a modified amino acid called D-Phenylalanine (D-Phe)
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Current use is limited to research purposes under physician supervision
In clinical research settings, this difference matters most in how each compound is measured: Tesamorelin has been studied in trials involving GH and IGF-1 level changes, while AOD-9604 research has focused specifically on lipolysis and fat oxidation markers without the same IGF-1 elevation a distinction documented in peer-reviewed pharmacology literature comparing hGH fragments to full GHRH analogs
HGH, our natural growth hormone, causes the liver to secrete insulin-like growth factor-1 (IGF-1)