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Currently, the drug Metformin is widely given as the first-line of treatment due to proven safety, its effectiveness and affordability
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The Q Exactive was operated using the Xcalibur software (Thermo Fisher Scientific) in data-dependent MS/MS mode, and the top 10 most intense ions with a charge state of +2 to +5 were selected with an isolation window of 2.0 m / z and fragmented by higher-energy collisional dissociation with a normalized collision energy of 28
A comparison of baseline demographics and clinical characteristics between GLP-1RAs and second- or third-line glucose-lowering medications is presented in ESM Tables 4 and 5
Rubber band When Q is finite, its convex hull is the unique convex polygon whose vertices are from Q and that contains all points of Q
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