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These studies have contributed to understanding the potential role of NNMT in metabolic disorders
Its effect is gradual and appears most pronounced when combined with a caloric deficit and regular physical activity
Based on investigational protocol reports and the clinical trial data, most subjects begin to see measurable changes in body composition at 4 to 6 weeks on a consistent daily protocol at 300 mcg
Prescribers should also be aware that the American Academy of Pediatrics policy statement on off-label prescribing recommends that clinicians "use the best available evidence, inform families clearly about the off-label nature of the treatment, and document the clinical rationale thoroughly" [14]
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