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Read more: Semaglutide side effects: Symptom guide & management tips Frequently asked questions about going on a semaglutide maintenance dose Why do people gain weight after stopping semaglutide
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The theoretical risk of over-activating the GH-IGF-1 axis, including acromegalic side effects and proliferative signaling, is additive
Gastrointestinal side effects, particularly diarrhea, occur in approximately 20-25% of semaglutide users during the first weeks of treatment
This finding highlights a fundamental distinction that must be applied when interpreting the preclinical literature as a whole: the majority of studies reporting positive outcomes employed a preventive or co-treatment paradigm, in which the drug was administered prior to or concurrently with pathological induction
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