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To minimize risks, follow your doctors prescription, avoid extended use unless directed, apply only to affected areas, monitor for unusual reactions, and consult your doctor if adverse effects arise

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Petersen N, Reimann F, Bartfeld S, Farin HF, Ringnalda FC, Vries RGJ, et al

Also, many function through non-canonical pathways, such as MOTS-c (16 aa) translocates to nuclei in senescent cells, directly repressing pro-aging transcription factors like NFAT 49

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