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Whereas NAD precursors aim to increase NAD directly, 5-Amino-1MQ takes a different route by inhibiting NNMT

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

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However, in most of the studies that included data on how many people stopped using the medication, the reactions were not strong enough to warrant stopping the injections