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GIP(3-30)NH 2 has been infused in both healthy individuals (16, 22, 24, 75), patients with type 1 diabetes (77), type 2 diabetes (78, p

Incretins and other peptides in the treatment of diabetes

Insulin resistance is the inadequate response of target tissues to the physiological effects of circulating insulin, such as decreased glucose uptake in skeletal muscles under insulin stimulation, inhibition of hepatic gluconeogenesis by insulin, and relief of the inhibitory effect of insulin on lipid breakdown in adipose tissue (Schenk et al., 2008)

The FDA required a "complete assessment of documentation systems used throughout your manufacturing and laboratory operations".1 This language indicates that the agency views the lack of computer controls as a gateway to broader documentation failures