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They discovered a protective mechanism by investigating how Chr-Chi NPs mitigate A-induced neurodegenerative diseases
While we observed no differences in the change in seizure severity between patients with hypocarnitinemia and normal free carnitine levels, Table 2 illustrates that 80% of our patients undergoing MAD reported less severe seizures or complete seizure freedom at the first timepoint, 85% at the second timepoint, and 86% at the third timepoint
Casares-Crespo et al., 2018)
Akyay , Selek A, Tarkun , ahin T, Cantrk Z, Arslan B, et al
While the largest percentage of intracellular iron is tightly bound to or incorporated into proteins as a cofactor or for storage, small portion of intracellular iron resides in the cytosol and intracellular organelles (e.g., lysosomes) and constitutes a redox-active liable iron pool, which regulates programmed cell death including ferroptosis 42
