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Metformin reduces the synthesis of pro-inflammatory cytokines in macrophages at a molecular level by blocking the transition from monocytes to macrophages via the AMPK-STAT3 pathway (Vasamsetti et al., 2015)
2024 Jan 10
This is hugely important, as it is the main reason doctors are so worried about Downs syndrome and other chromosomal disorders that can occur in the offspring of women over 35
From a dosing chart perspective, B12 addition does not change the tirzepatide dose itself
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