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Biguanides, once responsible for more than 35% of prescriptions, have steadily lost share as patients and providers increasingly turn to GLP1s

This compound has gained significant attention in preclinical and early clinical research due to its promising effects on body weight reduction, insulin sensitivity improvement, and lipid profile enhancement

Weight changes can affect optimal HRT dosing, particularly for transdermal preparations where absorption depends partly on body composition

"Alternative dosing regimens of GLP1 receptor agonists may reduce costs and maintain weight loss efficacy." Diabetes, Obesity and Metabolism 27.4 (2025): 2251-2258

57.3%), semaglutide (Oempic