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Retrieved 27 August 2017
According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment
This usually occurs when theres not enough sulfur group (-SH) available for detoxification, leading to increased oxidative stress
How Do You Know If You Have a Glutathione Deficiency
And the early growth response 1 (egr-1) gene expression pattern, originally identified in skin wound healing, also appears in muscle and tendon repair work, suggesting a shared transcriptional response
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