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In mouse models of DKD and TGF-treated HK-2 cells, pharmacological inhibition of ferroptosis via the selective inhibitor Ferrostatin-1 significantly suppresses HK-2 ferroptosis, attenuates tubular injury and renal damage (81)

Handa Y, et al

Augmentation therapy for alpha-1 antitrypsin deficiency: towards a personalised approach

Additionally, the expression of nuclear respiratory factor 1 and estrogen-related receptor (NRF-1 and ERR), which are downstream of PGC, is also inhibited, further exacerbating mitochondrial dysfunction and impeding gluconeogenesis