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some agents have shown reduction in major adverse cardiovascular events in specific populations [28] [29] Renal protection : slowing of diabetic kidney disease progression across the class Weight loss : modest reduction in body weight Blood pressure reduction : mild antihypertensive effect SGLT2 inhibitors do carry risks including genital mycotic infections and, rarely, euglycaemic diabetic ketoacidosis

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Tumor miR-125a was inversely associated with IGFBP-3 mRNA and, although no survival data were presented for IGFBP-3, its low tumor expression was correlated with increased tissue Akt activation [55]

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Tham LSSK, Geiser JS, Posada MM, Dickinson GL