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Because it is a naturally occurring compound involved in energy metabolism, adverse effects are rare

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However, a one-year randomized, double-blind, placebo-controlled trial in 253 elderly (65 years) adults with elevated homocysteine levels found that B vitamin supplementation (1,000 g/day of folate, 10 mg/day of vitamin B 6 , and 500 g/day of vitamin B 12 ) did not improve measures of cognitive function, including memory, despite lowering homocysteine levels (116)

Acetic acid is another diluent you might see mentioned, but it's typically reserved for peptides that are less soluble in water