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Specific dosing parameters vary significantly between studies and animal models researchers should reference the primary literature for protocol design
There are no data related to slight and moderate alterations, that also have clinical effects
Careful monitoring during treatment should be carried out to guarantee a safe outcome
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The euchromatin is characterized by an open state and is amenable to transcription, while the heterochromatin is characterized by a compact DNA-protein structure that cannot be transcribed (Jenuwein and Allis, 2001)
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