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In vitro cell culture Mouse proximal tubular cells TKPTS (CRL-3361) were purchased from ATCC and cultured in F-12 Medium (30-2006, ATCC) supplemented with 7% FBS (FBS, 30-2020, ATCC) and 0.06% insulin (10 mg/mL, 19278, Sigma)

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Therapeutic perturbation of the CoQ 10 redox axis therefore offers an attractive opportunity to sensitize tumors to ferroptotic cell death, particularly when combined with treatments that elevate oxidative stress or lipid peroxidation

people at higher risk of deficiency include older adults, those with gastrointestinal issues that impair absorption, people whove had gastric surgery, long-term strict vegans who do not supplement, and those on certain acid-reducing medicines