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The peptide has demonstrated efficacy in normalizing pathological blood pressure states, reversing hypertension induced by NOS inhibitors and attenuating hypotension induced by excessive NO substrate administration, indicating adaptive vascular regulation
The treatment effect was then evaluated using Cox proportional hazard regression, with cage assignment included as a random effect and batch as a covariate, using statistical software R (version 3.4.1) with package coxme
TOTOX is what we call it for short
J Urol 1997
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