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Production Methods of Glutathione Microbial fermentation method Modern industrial production of glutathione primarily relies on microbial fermentation using engineered strains of yeast or bacteria that overexpress enzymes in the glutathione biosynthesis pathway

Glutamyl-transpeptidase catalyzes the condensation of glutathione and the disulfide cystine to form gamma-glutamyl-cystine, which is then taken up and reduced intracellularly to form cysteine and gamma-glutamyl-cysteine (49)

10.1016/j.jpha.2025.101316 31 CungT.-T.MorelO.CaylaG.RioufolG.Garcia-DoradoD.AngoulvantD.et al (2015)

doi: 10.1007/s10565-010-9162-6 67 InnamoratoN

In the brain, glutathione helps maintain redox balance, reduce oxidative stress, and modulate immune signaling