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To build the R615C pig RyR1 open structure in complex with atorvastatin, we used the open rabbit RyR1:atorvastatin complex, modified by the program MODELER 55 to update pig-specific side chains, followed by rigid body refinement and several rounds of PHENIX real space refinement and ISOLDE

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Notably, passive transport rates are predominant or comparable to active transport rates for statins, except for rosuvastatin and fluvastatin

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