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Retatrutide trials show even stronger numbers
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Notably, DPP-4 inhibitors appear to be safe regarding the risk of fractures, as they tend to decrease this risk, but more clinical trials are needed to explore the effects of DPP-4 inhibitors in other populations beyond T2DM
This evaluation should include assessment of body mass index (BMI) to confirm eligibility (BMI 30, or 27 with at least one weight-related comorbidity such as hypertension, dyslipidemia, type 2 diabetes, or obstructive sleep apnea), previous weight loss attempts, and realistic expectations for treatment outcomes
Along those lines, the researchers observed an increase in lacrimal gland fibrosis in untreated aged mice
