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A case in point, when 2 different mouse strains were exposed to therapeutic or hepatotoxic doses of APAP, depletion of GSH or APAP protein adduct formation was only detected in the liver but not in the whole brain or individual brain regions, suggesting that there is no evidence for the formation of the reactive metabolite NAPQI in the brain of adult mice [185]
We are no longer simply treating disease
Teaching carbohydrate counting enables patients to match insulin doses to their food intake, providing flexibility in timing and content of meals
10.1016/j.bbapap.2005.05.010 22
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