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Low GLP activity is often linked with obesity, insulin resistance, and type 2 diabetes

These biopsybased endpoints supported accelerated approval for the MASH indication, but clinical benefit in terms of liverrelated outcomes (decompensation, transplant, mortality) remains to be fully demonstrated

Takechi, R

Lipohypertrophy can change your pharmacokinetic profile unpredictably, making timing optimization pointless because you no longer know how fast the drug is reaching your bloodstream

It sounds a cautionary note for short-term use without a more comprehensive approach to weight management. Overeating far more likely Adam Collins, associate professor of nutrition at the University of Surrey in England, who was not involved in the study, called the paper timely and important. Collins underlined that weight regain is a common issue in all weight loss interventions, but the paper shows that this problem is amplified with GLP-1 medications