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In addition, longer aliphatic chains (e.g., nonyl derivatives) often improve activity against Gram-positive bacteria and fungi but may reduce efficacy against Gram-negatives like E
Embaby, E
This pattern holds biological significance in PD in that it suggests that disease- or treatment-related effects may exert selective pressure on the microbial network in the gut without necessarily lowering the overall number of microbial species present, thereby exerting an influence on GBA signaling and L-DOPA metabolism
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