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The maintenance doses used in these trials include: 4 mg once weekly 9 mg once weekly 12 mg once weekly For those taking the maximum 12 mg dose , they follow a gradual increase that looks like this: 2 mg 4 mg 6 mg 9 mg 12 mg (highest dose studied) Each increase happens every 4 weeks , similar to the phase 2 studies, so the full build-up takes about 16 weeks before staying at 12 mg for the rest of the study
Summary Research regarding the effect of nutrient supplementation in the prevention and treatment of heart failure is at a very early stage, and there are no clear relationships at this time
It targets the GLP-1 receptor exclusively, producing average weight loss of 15 to 17 percent of body weight over 68 weeks in clinical trials
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