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If it is almost time for your next scheduled dose, skip the missed dose and continue your regular dosing schedule

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In addition, Caveolin-1 (Cav-1), a 21-kDa integral plasma membrane protein is a well-known negative regulator of eNOS activity in vascular endothelial cells 17,18,19,20,21,22

At oral supplementation doses (200 to 400 mg/day), the interaction is not clinically significant for most patients, but blood pressure should be monitored when starting supplementation in someone on amlodipine or diltiazem

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