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Although there have been a limited number of studies, we found that when normalized for neuronal volume using the MRS biomarker N-acetyl aspartate, there is clear evidence for an elevation of glutamate in the early progression of ALS which is consistent with the predictions of the model of increased activity of glutamatergic neurons leading to excitotoxicity

A review: Role of ultraviolet radiation in age-related macular degeneration

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Rome III, a set of criteria used to diagnose functional GI disorders, describes the diagnosis of chronic constipation as constipation for at least six months as well as specific symptoms for at least three months (eg, straining with at least 25% of bowel movements, details here)