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doi: 10.3389/fcvm.2021.795750 8 HigginsJPThompsonSG

Acta Pharmacol Sin 46 , 16641675 (2025)

However, current evidence suggests that the development of such antibodies does not significantly reduce the drugs effectiveness or cause any distinct adverse reaction profile

And that can be due to the shift of the hormones and the metabolic factors, which is, I think what's important to [00:25:00] understand is that while we focus through the lens of like weight loss and how much, you know, fat, how a bigger fat stores that what we're really focusing on what really is happening when you lose weight to the point we can be underweight and that can have a negative impact is that shift in the metabolic factors and in the hormones

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